Table 4.
Exosomal miRNAs as prognostic biomarkers in DLBCL.
| Study | Exosomal miRNAs | Sample | Source | Exosome isolation | miRNA Profiling | Result |
|---|---|---|---|---|---|---|
| Liu et al., 2021 (13), | miR-107 | 42 DLBCL vs. 31 controls | plasma | ExoEasy Maxi | qRT-PCR | Downregulation: ↓ PFS |
| Cao et al., 2021 (14), | miR-451a | 220 DLBCL (109 DLBCL analyzed for PFS vs. 111 DLBCL analyzed for OS) |
serum | ExoQuick | microarray qRT-PCR |
Downregulation: ↓ PFS and OS |
| Feng et al., 2019 (20), | miR-125b-5p miR-99a-5p |
116 DLBCL | serum | ExoQuick | RNA seq, qRT-PCR | Upregulation: ↓ PFS |
DLBCL, Diffuse large B-cell lymphoma; miR, microRNA; qRT-PCR, quantitative-Real time polymerase chain reaction; PFS, Progression-free survival; OS, Overall survival; ↓, Decreased.