Table 7.

Molecular pathways associated with exosomal miRNAs in DLBCL.

Study	Exosomal miRNAs	Molecular pathways	Result
Liu et al., 2021 (13),	miR-107	Targeting 14-3-3 η	Downregulation in DLBCL patients: ↓ PFS
Zare et al., 2020 (22),	miR-155-5P	Targeting INPP5D and SOCS-1	Upregulation in NK cells: ↓ proliferation and cytotoxicity
Feng et al., 2019 (20),	37miRNAs miR-125b-2-3p miR-99a-5p miR-10b-5p miR-125b-5p miR-146b-3p miR-23a-3p miR-1269a let-7c-5p miR-24-3p miR-novel-chr19 26407	AMPK signaling* Signaling pathways-regulating pluripotency of stem cells Cellular senescence MicroRNAs in cancer Ras signaling EGFR tyrosine kinase inhibitor resistance mTOR signaling p53 signaling Longevity regulating Autophagy – animal	Upregulation in DLBCL cell lines
Feng et al., 2019 (20),	17 miRNAs miR-122-5p miR-421 miR-144-5p miR-144-3p miR-98-5p miR-577 miR-novel-chr4 51772 miR-novel-chrX 72977 miR-novel-chr20 33917 miR-novel-chrX 73668	Signaling pathways- regulating pluripotency- of stem cells* TGF-beta signaling mTOR signaling Oocyte meiosis p53 signaling Proteoglycans in cancer Pathways in cancer MicroRNAs in cancer Transcriptional- misregulation in cancer cGMP-PKG signaling	Downregulation in DLBCL cell lines

*In the first pathway, all five miRNAs are involved and, in another pathway, some of them are involved.

miR, microRNA; PFS, Progression-free survival; ↓, Decreased.