Skip to main content
. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Ann Epidemiol. 2022 Mar 12;70:16–22. doi: 10.1016/j.annepidem.2022.03.003

Table 2.

Conditions sufficient for measures to be unbiased.

Number Descriptiona Scale Notationb Sufficient for these summary measures to be unbiased.
1 There is no bias in any group in any time period. Absolute α0,0 = α0,1 = α1,0 = α1,1 = 0. D^j, DıD^
Relative β0,0 = β0,1 = β1,0 = β1,1 = 1. R^j, PD^j, ROR^, RPD^
2 Bias is the same in all groups and time periods. Absolute α0,0 = α0,1 = α1,0 = α1,1 = α. D^j, DıD^
Relative 0 ≠ β0,0 = β0,1 = β1,0 = β1,1 = β. R^j, PD^j, ROR^, RPD^
3.1. Bias is the same between time periods within group. Absolute α0,0 = α0,1 = α0,t, and α1,0 = α1,1 = α1,t. D^j, DıD^
Relative 0 ≠ β0,0 = β0,1 = β0,t, and 0 ≠ β1,0 = β1,1 = β1,t. R^j, PD^j, ROR^, RPD^
3.2. Bias is the same between groups within time period. Absolute α0,0 = α1,0 = αj,0, and α0,1 = α1,1 = αj,1. DıD^
Relative 0 ≠ β0,0 = β1,0 = βj,0, and 0 ≠ β0,1 = β1,1 = βj,1. ROR^
4.1. The between-time-period trend in bias is the same between groups. Absolute α1,1α1,0α0,1α0,0 = αj,1αj,0. DıD^
Relative β1,1β1,0=β0,1β0,0=βj,1βj,0. ROR^
4.2. The between-group trend in bias is the same between time periods. Absolute α1,1α0,1α1,0α0,0 = α1,tα0,t. DıD^
Relative β1,1β0,1=β1,0β0,0=β1,tβ0,t. ROR^
5 Neither the between-time-period trend in bias is the same between groups, nor is the between-group trend in bias the same between time periods. Absolute α1,1α1,0 ≠ α0,1α0,0 and α1,1α0,1 ≠ α1,0α0,0. None
Relative β1,1β1,0β0,1β0,0, and β1,1β0,1β1,0β0,0. None
a

The meaning of the word trend in conditions 4.1. and 4.2 depends on the scale. Please refer to the notation for further precision.

b

For expressions involving the multiplicative bias factor, we stipulate that βj,t ≠ 0 so that the adjacent Yj,t does not drop out of the expression, creating unusual results.