Table 1.

Relative risk estimates of the association between genetically determined reproductive aging and coronary heart disease for individual studies and the pooled cohorts

	UK Biobank OR (95% CI)	m-CARDIoGRAM plusC4D OR (95% CI)	EPIC-CVD HR (95% CI)	Pooled relative risk estimates
Women
Simple median	0.99 (0.96-1.02)	0.97 (0.89-1.06)	0.97 (0.78-1.21)	0.99 (0.96-1.02)
Weighted median	0.99 (0.96-1.02)	0.97 (0.89-1.06)	1.08 (0.88-1.33)	0.99 (0.96-1.02)
IVW	0.99 (0.97-1.02)	0.98 (0.91-1.05)	1.02 (0.89-1.17)	0.99 (0.97-1.01)
MR-Egger	0.98 (0.94-1.02)	0.88 (0.76-1.02)	1.29 (0.91-1.83)	0.97 (0.94-1.02)
Men
Simple median	0.99 (0.95-1.02)	1.05 (0.99-1.12)	0.98 (0.81-1.18)	1.01 (0.98-1.04)
Weighted median	0.99 (0.96-1.03)	1.05 (0.99-1.12)	0.84 (0.71-1.01)	1.01 (0.98-1.04)
IVW	0.99 (0.96-1.01)	1.03 (0.99-1.08)	0.93 (0.82-1.05)	1.00 (0.97-1.02)
MR-Egger	0.98 (0.93-1.03)	1.02 (0.92-1.12)	0.85 (0.62-1.16)	1.00 (0.95-1.05)

Abbreviations: IVW, inverse-variance weighted; MR, Mendelian randomization; OR, odds ratio.