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. 2022 Apr 9;107(7):1888–1896. doi: 10.1210/clinem/dgac210

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Correlations in the alterations of the microbiota, metabolites, and clinical phenotypes in patients treated with empagliflozin or metformin. (A) Correlations in the changes in the microbiota, metabolites, and clinical phenotypes in patients treated with empagliflozin. (B) Correlations in the changes in the microbiota, metabolites, and clinical phenotypes in patients treated with metformin. Correlation coefficients were calculated using the method described by Bland and Altman. Red connections indicate the positive correlation (FDR < 0.05), whereas blue connections show correlations that were negative (FDR < 0.05). Abbreviations: DBP, diastolic blood pressure; FFA, free fatty acid; HbA1c, glycated hemoglobin; HOMA-IR, homeostasis model assessment of insulin resistance; IL-6, interleukin-6; PPG, postprandial plasma glucose; SBP, systolic blood pressure; UA, uric acid.