Table:

Serum markers of cholestasis from baseline through 72 months of OCA treatment

		Change from baseline
Mean (SD)	Baseline (N = 193)	12 months (N = 185)	72 months (N = 52)
Alkaline phosphatase (U/L)	317 (120)	–105 (88)*	–118 (128)*
Total bilirubin (μmol/L)	11.5 (7.0)	–0.9 (4.1)†	–0.1 (4.5)
Aspartate aminotransferase (U/L)	51.2 (33.5)	–12.8 (24.7)*	–14.1 (18.2)*
Alanine aminotransferase (U/L)	56.7 (37.0)	–21.5 (24.4)*	–28.2 (29.4)*
Gamma-glutamyl transferase (U/L)	275.2 (306.0)	–157.7 (205.1)*	–156.1 (200.1)*
Liver stiffness (kPa)†	11.4 (9.4)	0.5 (5.6)	1.2 (10.1)

*p <0.0001; † p = 0.004; † Baseline N = 79, 12 months N = 32; kPa, kilopascal.

p-values for the within-treatment comparisons were obtained using a paired t test.