TABLE 2.

In vivo experimental studies.

Study author/Year (References)	n	Animal model	Biological outcome	Pollutants	Exposure data
Qu et al. (2009)	—	Wistar rat	CFTR expression	O3	1-h per day 1.5 ppm O3 for 3 days
Shi et al. (2019)	6	BALB/c mice	Airway surface liquid secretion	Diesel particulate matter	0.5 mg, 10 μg/μl
			CFTR expression
Geiser et al. (2014)	2–35	Cftrtm1HGU mice	Lung function	TiO2 and CNP	1-h TiO2NP inhalation: 20 nm, 30–40 μg/m3
			Localization and biokinetics of NP
			Inflammation		CNP Intratracheal instillation: 5–12 nm, 20 μg, 0.4 μg/μl
Geiser et al. (2013)	2–4	Scnn1b-Tg mice	Cellular uptake and localization of NP	Au NP	2-h inhalation
					AuNP, 21 nm, 1.2 mg/m3

O₃, ozone;NP, nanoparticles; TiO₂, titanium dioxide; C, carbon; Au, Gold.