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. 2022 Jun 6;18(6):e1010126. doi: 10.1371/journal.pcbi.1010126

Fig 2. Cluster geometries and cytosolic domain.

Fig 2

(A) The five different RyR geometries studied in the model. The red dots show the single RyRs and the tan coloured area represents the junctional SR membrane. All five geometries contain 50 RyRs. The first two geometries (G1 and G2) contain a single cluster to simulate the healthy case. The latter 3 geometries (G3, G4, and G5) differ in the number of CRU sub-clusters, to simulate the disrupted RyR clusters observed during HF. G3, G4 and G5 are organized into 2, 3 and 12 sub-clusters respectively. (B) The computational domain of the cytosol is presented. The space corresponds 1.008 μm x 1.008 μm x 1.008 μm. The grey bars represent the non-junctional SR.