Figure 3. Simultaneous inactivation of frontal or posterior cortical areas confirms distinct contributions to sensory-evidence-based decisions.

Comparison of the effect of simultaneous posterior or frontal cortical inactivation on the use of sensory evidence as recovered from the mixed-effects logistic regression models combined across mice and inactivation epochs, with 10-fold cross-validation. For each area, we plot normalized evidence weights for inactivation trials as in Figure 2. Thin gray lines and crosses, mouse random effects (posterior: n=11, frontal: n=11). Error bars, ± SEM on coefficient estimates. Black circles below the data points indicate p-values from z-tests on the coefficients, with false discovery rate correction (captions on top, see Materials and methods for details).

Figure 3—figure supplement 1. Sensory-evidence information from different areas is combined unevenly.

Comparison between the effects of simultaneous inactivation of either posterior (left) or frontal (right) areas and the average of when the areas were individually inactivated. Error bars, ± SEM for model coefficient estimates. For the data averaged across areas, error bars correspond to the pooled SEM across conditions. Black circles below data points indicate p-values from z-tests on the coefficients, with false discovery rate correction. V1, primary visual cortex; mV2, medial secondary visual cortex; PPC, posterior parietal cortex; RSC, retrosplenial cortex; mM2, posteromedial portion of the premotor cortex; aM2, anterior portion of the premotor cortex; M1, primary motor cortex.