Fig. 2.
Longitudinal comprehensive PAM assessments of structural, functional, and oxygen-metabolic changes in the vascular tissue during wound healing, including (a) the hemoglobin concentration (CHb), (b) the oxygen saturation of hemoglobin (sO2), (c) blood flow speed, (d–e) tissue height and thickness, (f) oxygen extraction fraction (OEF), (g) volumetric blood flow (Flowv), and (h) the metabolic rate of oxygen (MRO2). White arrows in (a): vessels remodeled after inducing the puncture wound in the mouse ear. Dashed white circles in (a): hemorrhage. Red and blue arrows in (b): feeding arteries and draining veins analyzed in Fig. 3, respectively. The “0” position in (d) denotes the bottom of the ear vasculature. The locations of the B-scans in (e) are indicated by the white dashed lines in (d). Horizontal scale bar in (a): 500 µm. Vertical scale bar in (e): 50 µm.