FIG. 1.

Tissue blueprints for tissue constructs and significance of nuclear lamins. Human tissue atlases can serve, in principle, as “tissue blueprints,” which facilitate the understanding and regenerative engineering of tissue constructs. For example, atlases such as the scatterplots of single-cell RNA-seq data can help illustrate an association between Lamin-A,C expression (LMNA) and stiffness and also a distinct relationship of lamin-B1 (LMNB1) with cell proliferation. Note “fibs and endos” refers to fibroblasts and endothelial cells, “immune” refers to various types of immune cell lineages, and “parencym.” refers to the tissue-defining cells; the same data are explained in more detail in Fig. 2.