FIG. 2.

Snapshots of public data for expression of mechanosensitive and control genes. Tissue transcript patterns for collagen-1, the most abundant protein in animals, and for various mechanosensitive factors and related controls. Note that arteries are stiffer than brain, which is soft compared to skin, and of course, blood is fluid. The interested reader is urged to explore the website for details on each tissue shown and for RNA quantitation. Different colors indicate different tissue types from left to right: (adipose—subcutaneous; visceral); adrenal gland; (artery—aorta; coronary; tibial); bladder; (brain—amygdala; anterior cingulate cortex; caudate; cerebellar hemisphere; cerebellum; cortex; frontal cortex; hippocampus; hypothalamus; nucleus accumbens; putamen; spinal cord; substantia nigra); breast—mammary tissue; (cells—EBV-transformed lymphocytes; cultured fibroblasts); (cervix—ectocervix; endocervix); (colon—sigmoid; transverse); (esophagus—gastroesophageal junction; mucosa; muscularis); fallopian tube; (heart—atrial appendage; left ventricle); (kidney—cortex; medulla); liver; lung; minor salivary gland; muscle—skeletal; nerve—tibial; ovary; pancreas; pituitary; prostate; (skin—not sun exposed; sun exposed); small intestine—terminal ileum; spleen; stomach; testis; thyroid; uterus; vagina; whole blood. (a) Scatterplots of bulk tissue RNAseq data from the ENCODE website (GTEx-V8) and from the Human Protein Atlas website (HPA21.0). Each datapoint is the mean for a tissue. (b) Regulation of lamin-B1 gene expression based on ChIP-seq targeting FOXM1 in two cultured cell types with nonzero signal from high (black) to low (light gray). (c) Single-cell RNAseq of liver cancer (Vashisth et al., 2021).