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miR-130a-3p directly binds to and regulates the expression of ALK2. (a) The predicted binding sites of miR-130a-3p to ALK2 sequence using StarBase. ((b) and (c)) The expression of ALK2 protein was detected by Western blot. (d) The relative luciferase of HEK 923 cells was transfected with miR-130a-3p mimics or inhibitors and luciferase constructs of WT- or MUT-ALK2-UTR. ∗∗P < 0.01.
