Figure 7.

Knockdown of XIST alleviates iron overload-induced pancreatic islets/beta cells injury in T2D rats. ((a) and (b)) The gene expression was detected by RT-qPCR. (c) The expression of ALK2 protein was detected by Western blot. (d) The body weight of each group rats. (e) Comparison of postprandial and fasting blood glucose concentration of differently treated rats. ((f), (g), (h)) Comparison of iron, TIBC, and ferritin constituent in serum from each group. (i) Comparison of iron metabolic-related proteins of differently treated rats. (j) The H&E and insulin staining in pancreatic tissues. Scale bar = 100 μm. ^∗P < 0.05, ^∗∗P < 0.01.