Table 2.
Characteristics between responder and non-/weak responder
| Responder (n = 18) | Non-/weak responder (n = 5) | P | |
|---|---|---|---|
| Gender (male) | 17% | 0% | 0.999 |
| Autoimmunity | 17% | 80% | 0.017 |
| Malignancy | 17% | 50% | 0.210 |
| Age | 48 ± 20 | 50 ± 10 | 0.790 |
| Baseline values prior to initiation of IgG replacement | |||
| IgG | 671 ± 240 | 228 ± 119 | < 0.0001 |
| IgM | 86 ± 111 | 241 ± 354 | 0.215 |
| IgA | 110 ± 78 | 47 ± 28 | 0.001 |
| IgG1 | 443 ± 148 | 99 ± 86 | 0.010 |
| IgG2 | 163 ± 105 | 43 ± 22 | 0.022 |
| IgG3 | 34 ± 23 | 29 ± 10 | 0.110 |
| IgG4 | 14 ± 15 | 6 ± 7.2 | 0.155 |
| Laboratory data (%) | |||
| CD3 | 72 ± 7 | 78 ± 12 | 0.177 |
| CD4 | 66 ± 10 | 53 ± 20 | 0.228 |
| CD8 | 20 ± 8 | 15 ± 12 | 0.118 |
| CD8 naive | 36 ± 21 | 27 ± 18 | 0.021 |
| CD8 CM | 11 ± 8 | 9 ± 10 | 0.465 |
| CD8 EM | 26 ± 12 | 30 ± 12 | 0.047 |
| CD8 EMRA | 24 ± 20 | 32 ± 14 | 0.126 |
| CD19 | 8 ± 5 | 5 ± 3 | 0.023 |
| CD19 CD27+ IgD−IgM− | 23 ± 12 | 9 ± 2 | 0.004 |
| CD19 CD27− CD21low | 38 ± 27 | 55 ± 26 | 0.166 |
| cTfh (PD-1+) cells | 2.5 ± 1.4 | 3.3 ± 3 | 0.555 |
| cTfh (PD-1-) cells | 8.5 ± 2.6 | 9.8 ± 3.1 | 0.425 |
Abbreviations: CM central memory, EM effector memory, EMRA CD45RA positive EM, cTfh circulating T follicular helper cells. P-values marked with bold indicate statistically significant p-values