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. 2022 Jun 6;24(6):872–884. doi: 10.1038/s41556-022-00925-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — (a)The mammalian HK2 protein sequence was evaluated for nuclear localizing signals using the SeqNLS algorithm. (b) NLS conservation in HK2 of Homosapiens, Mus Musculus and Macaca mulata analysed using Clustal omega. (c)The predicted sequences and the positions of HK2 Nuclear Export Sequence by NESX1 library using Pattinprot and ELM library. (d) Representative confocal images of DuoLink Promity Assay interactions. Scale bar = 10µm. Representative image from 3 biologic repeats. (e) Clustering on peaks using DiffBind comparing NB4 cells transduced with NLS1-HK2 and EV. (f) Clustering on peaks using DiffBind comparing NB4 cells overexpressing OMMLS HK2 transduced with control sequences or shRNA targeting the UTR of HK2. (g) Heatmap plots of differentially accessible regions in NB4 cells overexpressing NLS1-HK2 or EV. (h) Heatmap plots of differentially accessible regions in NB4 cells overexpressing OMMLS HK2 transduced with control sequences or shRNA targeting the UTR of HK2. (i) Number of Differentially Accessible Regions in NB4 cells with NLS1-HK2 or EV measured by ATAC sequencing. (j) Number of Differentially Accessible Regions in NB4 cells overexpressing OMMLS HK2 transduced with control sequences or shRNA targeting the UTR of HK2 measured by ATAC sequencing.