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. 2022 Jun 6;24(6):872–884. doi: 10.1038/s41556-022-00925-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — (a) Network representation of NLS1-HK2 and NLS2-HK2 ChIP–seq pathways with higher enrichment scores compared to EV. Node size is proportional to the ratio of NLS1/2 to EV at FDR < 0.05 using a Fisher’s exact test. (b) Known motifs from HOMER significantly enriched in both NLS1 and NLS2-HK2 peaks at FDR<0.05. (c) Venn plot showing significantly enriched motifs in NLS1 HK2 and NLS2 HK2 at FDR<0.05 using Fisher’s exact test. (d) Venn diagram shows bHLH motifs among the common HOMER motifs between NLS1 HK2 and NLS2 HK2. Fisher’s exact test p value for the enrichment of this motif is 0.0006631. (e) Multiple alignment of the motifs using the UGene tool showing the frequency of each nucleotide identifying the consensus sequence. (f) Enrichment of consensus sequence in the specified pathways. (g) Peak distribution around TSS of genes in each individual ChIP–seq biological replicates. (h) Peak distribution of individual replicates relative to promoters, intronic or intergenic regions. (i) Clustering on identical peaks using the DiffBind tool shows that NLS1-HK2 and EV group separately.