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. 2022 Jun 13;24(6):858–871. doi: 10.1038/s41556-022-00932-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, UMAP projection of the human pre-implantation and postimplantation embryo integration with day 4 (D4) in vitro trophoblast conversion with and without PRC2i. Human embryo data from^3,74. b, UMAP projection of embryo trophectoderm and embryo trophoblast on the UMAP from a. c,d, UMAP projection of D4 trophoblast cells in C2 with (d) and without (c) PRC2i treatment projected on the UMAP from a. The clusters correspond to those in Fig. 5d–f. Dotted lines represent the embryo trophectoderm (orange) and embryo trophoblast (green) as shown b. e, Proportion of D4 trophoblast conversion cells, with and without PRC2i, that were categorized as belonging to the C2 trophoblast cluster. Source data are provided.

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