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(a) Generalized schematic of modeling the intestinal concentrations of antimicrobials in the host's intestine. In simple font are the processes that have been characterized in PK models related to therapeutic effects of antimicrobial drugs. In Italics and underlined are further processes that need to be characterized. (b) Adaptation of the framework for oral CTC treatment in cattle. (c) Adaptation of the framework for parenteral treatment by cephalosporin ceftiofur in cattle.
