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. 2022 Jun 16;5:591. doi: 10.1038/s42003-022-03529-z

Fig. 1. Phenome-wide associations between GRSs for iron status biomarkers and 1473 phecodes, blood biomarkers, and continuous traits in the UK Biobank.

Fig. 1

Phenome-wide associations between the GRS for each biomarker (serum iron [a], serum ferritin [b], total iron-binding capacity [c], and transferrin saturation percentage [d]) and 1473 phecodes, blood biomarkers, and continuous traits in the UK Biobank. Triangles pointing upwards indicate a positive association between the phenotype and the GRS (where a higher GRS score represents higher level of the biomarker) and vice versa. Associations with p-values < 10−324 are plotted at 10−324. The Bonferroni corrected p-value cut-off (2.3 × 10−7) is given as a red dotted line. Biological domains are indicated by color; for the significant associations, these are: hematopoietic (orange), anthropometric (dark blue), circulatory system (red), respiratory (brown), digestive (light green), genitourinary (yellow), musculoskeletal (dark green), endocrine/metabolic (magenta), symptoms (light blue). Abbreviations: MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, dist. distribution, Cong. def. congenital deficiencies, HbA1c glycated hemoglobin, SHBG sex hormone-binding globulin, LDL low-density lipoproteins, Apo B apolipoprotein B, IGF-1 insulin-like growth factor 1, FEV1 forced expiratory volume (1 s), FVC forced vital capacity, ALP alkaline phosphatase, ASAT aspartate aminotransferase, ALAT alanine aminotransferase, GGT gamma-glutamyl transferase. a: 1Other anemias, 2Impedance, 3FEV1, 4FVC, 5Total protein, 6Cystatin C, 7Phosphate, 8Apo B, 9Testosterone, 10IGF-1, 11Cholesterol, 12LDL. b: 1Anemias (iron deficiency and other anemias), 2Platelet indices (platelet count, platelet crit, platelet dist. width), 3White blood cell counts (lymphocytes, leukocytes, monocytes), 4Seated height, 5Water mass, 6Fat-free mass, 7Phlebitis and thrombophlebitis, 8Non-alcoholic liver disease, 9Gamma-glutamyl Transferase, 10Direct bilirubin, 11Urate, 12Creatinine. c: 1Mean platelet volume, 2Platelet crit, 3Platelet dist. width., 4FEV1, 5FVC, 6Liver cirrhosis, 7Cystatin C, 8Phosphate. d: 1Other anemias, 2Monocyte percentage, 3Congenital deficiency of other clotting factors, 4FEV1, 5FVC, 6ALAT, 7Cystatin C, 8Phosphate, 9LDL, 10Apo B, 11IGF-1, 12Cholesterol, 13Testosterone.