Table 2.
Performance of CSF biomarker cutoffs.
| CSF biomarkers | Cutoff | AUC (95% CI), % | AIC | Sensitivity, % | Specificity, % | Accuracy, % |
|---|---|---|---|---|---|---|
| Aβ42 | <933 pg/mL | 94.0 (90.4, 97.5) | 106.41 | 89.1 | 87.6 | 88.2 |
| P-tau181 | >48.7 pg/mL | 70.3 (61.0, 79.1) | 197.40 | 70.3 | 68.6 | 69.2 |
| T-tau | >313 pg/mL | 83.2 (75.3, 89.3) | 160.50 | 65.6 | 90.5 | 81.1 |
| AT | >−0.461 | 94.3 (90.9, 97.6) | 104.97 | 85.9 | 90.5 | 88.8 |
| AN | >−0.368 | 94.9 (91.9, 98.0) | 99.22 | 90.6 | 89.5 | 89.9 |
| TN | >36.3 | 82.5 (75.6, 89.4) | 156.40 | 68.8 | 87.6 | 80.5 |
| ATN | >−0.173 | 95.0 (92.0, 98.1) | 100.91 | 89.1 | 91.4 | 90.5 |
| ANA’ | >0.332 | 95.5 (92.5, 98.6) | 95.47 | 87.5 | 92.4 | 90.5 |
| ANA’E | >−0.401 | 96.0 (93.2, 98.9) | 93.31 | 90.6 | 90.5 | 90.5 |
| ANA’ES | >−0.421 | 96.2 (93.2, 99.1) | 94.67 | 92.2 | 89.5 | 90.5 |
CSF cerebrospinal fluid, AUC area under the curve, AIC Akaike information criterion, CI confidence intervals.
A, Aβ42; T, P-tau181; N, T-tau; A’, age; E, apolipoprotein E ε4 allele (APOE ε4) status.
AT = 3.944–0.006A + 0.018T; AN = 3.164–0.005A + 0.004N; TN = −2.629–0.034T + 0.14N; ATN = 3.392–0.005A–0.009T + 0.005N; ANA’ = 8.003–0.005A + 0.006N–0.075A’; ANA’E = 7.803–0.005A + 0.006N–0.079A’ + 1.008E; ANA’ES = 7.66–0.005A + 0.006T–0.081A + 1.024E + 0.459S (established by logistic regression).