Table 3.
Drug release kinetics of levofloxacin from nano-drug formulation at various pH media (5.5, 7.4, and 10.5).
| Model | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| pH | Zero order | First order | Higuchi | Korsmeyer-Peppas | |||||
| R2 | K0(h-1) | R2 | K1(h-1) | R2 | KH (h-1/2) | R2 | Kkp | n | |
| Acidic | 0.8127 | 3.0117 | 0.8609 | 0.0894 | 0.9101 | 10.6350 | 0.9491 | 45.290 | 1.1861 |
| Neutral | 0.9301 | 0.2546 | 0.9418 | 0.0964 | 0.8527 | 1.8693 | 0.8876 | 6.9323 | 1.0685 |
| Basic | 0.3653 | 1.0292 | 0.3766 | 0.1161 | 0.4331 | 3.8042 | 0.4670 | 7.850 | 0.5738 |
R2 Determination coefficient, k0 Zero-order rate, k1 First-order rate, KH Higuchi release rate, KKP Korsmeyer–Peppas release rate, n n factor in Korsmayer–Peppas model.