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. 2022 Jun 16;13:3463. doi: 10.1038/s41467-022-31196-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Treatment interventions induced significantly lower setpoint viral loads as compared to sham (left). There was no association of virologic control with pre-ART peak viral loads in the Ad26/MVA vaccinated animals (right). Two-sided Mann–Whitney tests used to determine significance. b PGT121 treatment significantly delayed viral rebound. The Kaplan–Meier plot shows the significant difference between the PGT121 groups and sham group, determined via the Mantel-Cox log-rank test (PGT121, χ² = 14.37, p = 0.0001; Ad26/MVA + PGT121, χ² = 14.85, p = 0.0001). The dot-plot visualizes the days to rebound (median indicated in red). Two-sided Mann–Whitney tests used to determine significance. Sham = sham treatment; PGT121 + VES = PGT121 + vesatolimod treatment; Ad26/MVA + VES = Ad26/MVA + vesatolimod treatment; and Ad26/MVA + PGT121 + VES = Ad26/MVA, PGT121, + vesatolimod treatment. Horizontal red lines indicate median values. ***p < 0.001 (in a, p = 0.0008; in b, p = 0.0002), ****p < 0.0001.