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. 2022 Jun 16;13:3407. doi: 10.1038/s41467-022-30194-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a A phylogenetic tree of five mammalian species analysed in this study. Distances are not to scale, timeline based on the Timetree tool⁸⁵. Icons represent implantation modes in given species. MYA million years ago; values indicate time separating human from a given species. b PCA of samples from the human compiled dataset^50–52. N numbers of individual groups are as follows: Zy CS1 = 3, 4 cell CS2 = 10, 8-cell CS2 = 94, cMor CS3 = 29, ICM CS3 = 66, Epi CS3 = 54, Epi CS7 = 147. d PCA of cynomolgus monkey samples⁵⁵. N numbers of individual groups are as follows: ICM CS3 = 29, Epi CS3 = 68, EmDisc CS5 = 26, EmDisc CS6/7 = 129. f PCA of marmoset samples (Bergmann et al.⁵⁶). N numbers of individual groups are as follows: Zy CS1 = 3, 4-cell CS2 = 12, 8-cell CS2 = 15, cMor CS3 = 53, ICM CS3 = 42, Epi CS3 = 38, EmDisc CS5 = 24, EmDisc CS6 = 46, EmDisc CS7 = 33. h PCA of porcine samples^57,58. N numbers of individual groups are as follows: Zy CS1 = 3, 4-cell CS2 = 14, 8-cell CS2 = 26, cMor CS3 = 47, ICM CS3 = 24, Epi CS3 = 25, EmDisc CS5 = 48. (j) PCA of opossum samples⁵⁹. N numbers of individual groups are as follows: Zy CS1 = 7, 4-cell CS2 = 21, 8-cell CS2 = 62, Blast CS3 = 55, Pluri CS3 = 140, Epi CS3 = 26, Epi late CS3 = 51, EmDisc CS5 = 106. c, e, g, i, k Boxplot graphs of scores for glycolysis and OxPhos modules in cell clusters representing embryonic tissues in datasets shown to the left of each graph. The boxplots are defined by the 25th and 75th percentiles, with the centre as the median. The minima and maxima extend to the largest value until 1.5 of the interquartile range (IQR) and the smallest value at most 1.5 of IQR, respectively. CS Carnegie stage, ZY zygote, 4-cell 4-cell stage, 8-cell 8-cell stage, cMor compacted morula, ICM inner cell mass, Epi epiblast, EmDisc embryonic disc, Tb trophoblast, Hyp hypoblast, VE visceral endoderm, AM amnioid, SYS secondary yolk sac, PGC primordial germ cells, ExM extraembryonic mesoderm, Blast blastocyst, Pluri pluriblast.