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. 2022 Jun 16;13:3407. doi: 10.1038/s41467-022-30194-x

Fig. 5. An evolutionary conserved switch from bivalent to glycolytic metabolism in mammalian development upon embryonic disc formation.

Fig. 5

Single-cell RNA-seq data from six species stage-matched according to the Carnegie system allowed elucidation of the transcriptional programme of metabolic enzymes. This metabolic programme is characterised by low glycolytic activity during cleavage, followed by a peak in OxPhos during the formation of the blastocyst (CS3) and an increase in glycolytic flux at the time of embryonic disc formation (CS5), regardless of species or time of implantation. CS Carnegie stage, Zy zygote, cMor compacted morula, ICM inner cell mass, Epi epiblast, EmDisc embryonic disc, Blast blastocyst, Pluri pluriblast, E embryonic day.