Fig. 2. Expression QTL map of 207 wild C. elegans strains.
a Heritability for 25,849 transcript expression traits with (orange) or without (black) detected eQTL. The narrow-sense heritability (h2, y-axis) for each trait is plotted against the broad-sense heritability (H2, x-axis). b The genomic locations of 6,545 eQTL peaks (x-axis) that pass the genome-wide EIGEN 5% FDR threshold are plotted against the genomic locations of the 5,291 transcripts with expression differences (y-axis). Golden points on the diagonal of the map represent local eQTL that colocalize with the transcripts that they influence. Purple points correspond to distant eQTL that are located farther away from the transcripts that they influence. c The variance explained (VE) by each detected eQTL (y-axis) that passed Bonferroni (BF) 5% FDR or EIGEN 5% FDR threshold for each trait is plotted against the narrow-sense heritability h2 (x-axis). The dashed lines on the diagonal are shown as visual guides to represent h2 = H2 (a) and VE = h2 (c). d Comparison of VE between 3185 local and 3,360 distant eQTL shown as Violin plots. The mean and median VE by local or distant eQTL are indicated as red points and horizontal lines in each box, respectively. Box edges denote the 25th and 75th quantiles of the data, and whiskers represent 1.5× the interquartile range. Statistical significance was calculated using a two-sided Wilcoxon test. e A histogram showing the number of distant eQTL detected per transcript expression trait. One to six distant eQTL were detected for 2,553 transcript expression traits, of which 447 traits also have one local eQTL. Numbers before slashes (indicated as the golden proportion of each bar) represent the number of traits with a local eQTL in addition to their distant eQTL. Numbers after each slash represent the total number of traits in each category.