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. 2022 Jun 3;13:913215. doi: 10.3389/fimmu.2022.913215

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Copyright © 2022 Coënon and Villalba

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Different strategies to improve ADCC. NK cell-mediated ADCC can be enhanced by expanding them with specific protocols or by stimulating them with certain cytokine cocktails. It could be possible to select more potent NK cell subsets based on their phenotype or genotype. Engineering mAbs are also an efficient way to increase ADCC activity. Lastly, tumor cells can be sensitized to NK cell activity by modifying their metabolism. ADCC, antibody-dependent cell-mediated cytotoxicity; Ag, antigen; CIML NK, memory-like natural killer cells; mAbs, monoclonal antibodies.