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. 2022 Jun 3;13:885026. doi: 10.3389/fneur.2022.885026

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Copyright © 2022 Bieniussa, Kahraman, Skornicka, Schulte, Voelker, Jablonka, Hagen and Rak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DPOAE analysis in dB SPL at recorded frequencies. (A) DPOAE recorded hearing threshold at p21. Treated and untreated PMN mice had a significant increase at 12, 16, 20, and 24 kHz (p < 0.01) compared to the control littermates. (B) A slope function at 8 kHz showed no significantly different slope function between the three groups. (C) At p28, PMN mice had an increased threshold at 8, 12, 16, 20, and 24 kHz (p < 0.001). (D) At this age, the slope function showed a significant reduction in untreated PMN (p < 0.05) and treated PMN mice (p < 0.01) compared to the wildtype animals. DPOAE thresholds: Regular two-way ANOVA with multiple comparison tests and post hoc Tukey analysis. Slope function: Ordinary one-way ANOVA with multiple comparison tests and Holm-Sidak post hoc analysis. Significances: *p < 0.05, **p < 0.01, ***p < 0.001.