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. 2022 Jun 3;13:885026. doi: 10.3389/fneur.2022.885026

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Copyright © 2022 Bieniussa, Kahraman, Skornicka, Schulte, Voelker, Jablonka, Hagen and Rak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ABR click and tone hearing threshold. (A) Hearing threshold of click ABR and (B) frequency-specific thresholds at p21 in dB SPL. Click ABR showed an increased threshold in PMN mice (p < 0.01) and tone-specific ABR indicated an increased threshold at the higher frequencies of 20 and 24 kHz (p < 0.01). Peg-IGF-1 had no benefit on the click and tone-specific ABR. Similar results could be seen in (C) the threshold of click ABR and (D) frequency-specific thresholds at p28. Click ABR analysis showed an increased threshold of both PMN groups (p < 0.001) and an increasing threshold at the frequencies 8 (p < 0.05), as well as 12, 16, 20, and 24 kHz (p < 0.001). Click ABR threshold: Ordinary one-way ANOVA with multiple comparison test and Hold-Sidak post hoc analysis. Tone ABR: Regular two-way ANOVA with multiple comparison tests and Tukey post hoc analysis. Significances: *p < 0.05, **p < 0.01, ***p < 0.001.