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. 2022 Jun 16;13:3167. doi: 10.1038/s41467-022-30828-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a A schematic diagram illustrating the experimental set-up. Conjunctive stimulus [PF/ΔV-stim, 30× (PF stimuli plus Purkinje cell depolarization) at 1 Hz] was applied to induce LTD at PF–Purkinje cell synapses (LTD-stim). An orientation of stimulus and recording electrodes and stimulus conditions are shown. b Averaged data of LTD recordings from mGlu1^+/+ (black circles) and mGlu1^CBC/CBC (red circles). Insets, representative PF-EPSC traces just before (blue; t = −1 min) and 30 min after (black and red) LTD-stim in mGlu1^+/+ and mGlu1^CBC/CBC mice, respectively. A right graph shows a cumulative probability of the degree of LTD at t = 30 min. [n = 7 cells from 4 mice (mGlu1^+/+) or 6 cells from 4 mice (mGlu1^CBC/CBC)]. c, d Averaged data of DHPG-induced (c) or Pd(sulfo-bpy)-induced (d) chemLTD recordings from mGlu1^+/+ (black circles), mGlu1^CBC/CBC (red circles) and mGlu1^CBC/+ (green circles in d) mice. Insets, representative PF-EPSC traces just before (blue; t = −1 min) and 25 min after (black, red, or green) drug washout in each mouse group. A right graph shows a cumulative probability of the degree of LTD at t = 35 min. [n = 7 cells from 4 mice (mGlu1^+/+) or 8 cells from 5 mice (mGlu1^CBC/CBC) in c and n = 8 cells from 5 mice (mGlu1^+/+), 11 cells from 6 mice (mGlu1^CBC/CBC) or 8 cells from 5 mice (mGlu1^CBC/+) in d]. Data are presented as mean ± s.e.m.