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. 2022 Jun 16;5:598. doi: 10.1038/s42003-022-03539-x

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© The Author(s) 2022, corrected publication 2022

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Fig. 8 — a, b Distribution of circ_0076611 expression in tumors from the TMA (Ck5+) characterized by different strength of ID4 protein expression. Two-tailed p value has been calculated by Chi-square test comparing circ_0076611-negative vs. circ_0076611-positive cases, in the two groups with ID4-low vs. ID4-medium/high. Representative images of various ID4 staining intensities, as assessed by immunohistochemistry (IHC), are shown in b. c Venn diagram indicating the intersection between circ_0076611 target mRNAs and transcripts positively or negatively correlated to ID4 in the TCGA basal-like breast cancer dataset. 19-negatively and 27-positively ID4-correlated genes that are also bound by circ_0076611 were identified. d Kaplan–Meier analysis showing the association between the expression of the two combined signatures of 19-negatively (19dn) and 27-positively (27up) ID4-correlated genes identified in c and survival [distant-metastasis free survival, DMFS (N = 275); recurrence-free survival, RFS (N = 417)] in BLBC patients. Survival analyses were performed using the KMplot database (www.kmplot.com) considering the mean expression of the selected genes. Evaluation of combined signatures (up/dn) has been performed by setting the 19dn signature as “inverted” in the KM plotter. “Best cutoff” setting was used to split patients. Asterisks refer to logrank p (**p < 0.005, ***p < 0.0005). e Kaplan–Meier analysis showing the association between the expression of the two groups of 19-negatively (19dn) and 27-positively (27up) ID4-correlated genes identified in c and survival [distant-metastasis free survival, DMFS (N = 275); recurrence-free survival, RFS (N = 417)] in BLBC patients. Survival analyses were performed using the KMplot database (www.kmplot.com) considering the mean expression of the selected genes and using the median value to split the patients. Asterisks refer to logrank p (*p < 0.05, ***p < 0.0005).