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. 2022 Jun 16;12:10040. doi: 10.1038/s41598-022-14319-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Construction of a PPI network and the identification of hub genes. (A) PPI network of DEGs. The outer circle represents upregulated genes, The outer circle represents downregulated genes, and the darker the color, the stronger the connection between the gene and other genes. (B) Top 15 DEGs obtained by MCC of cytohubba. DEG differentially expressed gene, PPI protein–protein interaction, MCC maximal clique centrality.