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. 2022 Jun 16;12:10040. doi: 10.1038/s41598-022-14319-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cell communication network diagram. (A) The number of ligand receptor interactions detected between different cell types. (B) Ligand receptor contribution to the overall signaling pathway. The CCL5/CCR1 ligand receptor pair contributed the most, followed by the SELPLG/SELL ligand receptor pair. (C) Receptor ligand pair interactions between immune cells. (D) The distribution and expression level of signal genes involved in the three signal pathway networks.