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. 2022 Jun 3;9:859422. doi: 10.3389/fcvm.2022.859422

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Copyright © 2022 Huang, Li, Huang, Wang, Liu, Luo, Gan, Fu, Zou, Chen and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Notopterol improves right ventricular function and reduces right ventricular systolic pressure in pulmonary arterial hypertension rats. (A) The right ventricular pressure waveform. Quantification of RVSP, (B) PAT, (C) PET, (D) PAT/PET, (E) LVEF, (F) 3 weeks after MCT injection (n = 8 for each group); *p < 0.05, **p < 0.01, ***p < 0.001. MCT, monocrotaline; Veh, vehicle; PAT, pulmonary blood flow acceleration time; PET, pulmonary ejection time; PAT/PET, pulmonary blood flow acceleration time/ pulmonary ejection time; RVSP, right ventricular systolic pressure.