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. 2022 Jun 3;9:859422. doi: 10.3389/fcvm.2022.859422

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Copyright © 2022 Huang, Li, Huang, Wang, Liu, Luo, Gan, Fu, Zou, Chen and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Notopterol reduces right ventricular hypertrophy and fibrosis in pulmonary arterial hypertension rats. (A) Quantification of Masson staining; (B) Representative histopathological images of RV sections with Masson staining for collagen deposition (40 ×); (C) Quantification of Myocyte area; (D) Myocyte area. Representative cross-section cardiomyocytes (40 ×); (E) RV hypertrophy index; (F) RV mRNA expression of collagen I. (n = 8 for each group); *p < 0.05, **p < 0.01, ***p < 0.001. IVS, interventricular septum; LV, left ventricle.