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. 2022 Jun 3;9:859422. doi: 10.3389/fcvm.2022.859422

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Copyright © 2022 Huang, Li, Huang, Wang, Liu, Luo, Gan, Fu, Zou, Chen and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Notopterol eases pulmonary vascular remodeling. (A) Representative H&E staining micrograph of lung tissue sections (100 ×); (B) Quantification of the medial wall thickness of the small pulmonary arteries (n = 8 for each group); (C) Expression of α-SMA in lungs evaluated with immunohistochemistry staining (100 ×); (D) Quantification of the arteries muscularization of the small pulmonary arteries (n = 8 for each group); (E) Western blots of PCNA in lungs; (F) Quantification of PCNA expression in the lungs. (n = 4 for each group). *p < 0.05, **p < 0.01, ***p < 0.001. H&E, hematoxylin-eosin; α-SMA, α-smooth muscle actin; PCNA, proliferating cell nuclear antigen.