Table 3.
Baseline characteristics by new medication and new device classes
| New Medication Classes |
New Device Classes |
|||||
|---|---|---|---|---|---|---|
| Patient Characteristics | 0 (N = 152) |
1-2 (N = 106) |
3+ (N = 50) |
0 (N = 206) |
1-2 (N = 92) |
3+ (N = 10) |
| Age (years) | 8 [3, 13] | 4 [1, 10] | 7 [2, 14] | 7 [2, 13] | 6 [2, 12] | 10 [7, 12] |
| Sex: Male | 79 (52%) | 61 (58%) | 29 (58%) | 115 (56%) | 50 (54%) | 4 (40%) |
| ADI (national rank)1 | 31 [18, 65] | 30 [13, 65] | 39 [12, 77] | 31 [15, 61] | 37 [15, 77] | 20 [15, 51] |
| Health insurance status2 | ||||||
| Private insurance | 63 (41%) | 45 (42%) | 27 (54%) | 88 (43%) | 41 (45%) | 6 (60%) |
| State Medicaid | 82 (54%) | 55 (52%) | 20 (40%) | 106 (51%) | 47 (51%) | 4 (40%) |
| Other/Unknown | 7 (5%) | 6 (6%) | 3 (6%) | 12 (6%) | 4 (4%) | 0 (0%) |
| Pre-sepsis FSS | 6 [6, 13] | 6 [6, 10] | 7 [6, 11] | 6 [6, 11] | 7 [6, 12] | 11 [8, 15] |
| PMCA3 | ||||||
| No chronic conditions | 81 (53%) | 47 (44%) | 22 (44%) | 106 (51%) | 42 (46%) | 2 (20%) |
| Chronic conditions (non-complex) | 7 (5%) | 6 (6%) | 4 (8%) | 12 (6%) | 5 (5%) | 0 (0%) |
| Chronic conditions (complex) | 63 (41%) | 53 (50%) | 24 (48%) | 87 (42%) | 45 (49%) | 8 (80%) |
| Day 1 PELOD4 | 8 [6, 10] | 7 [6, 10] | 9 [7, 12] | 8 [6, 10] | 9 [7, 12] | 8 [5, 10] |
| PRISM III5 | 10 [5, 15] | 10 [6, 17] | 12 [8, 19] | 11 [6, 16] | 10 [6, 16] | 12 [9, 17] |
| Infectious disease status6 | ||||||
| Suspected | 96 (63%) | 58 (55%) | 26 (52%) | 124 (60%) | 51 (55%) | 5 (50%) |
| Documented | 56 (37%) | 48 (45%) | 24 (48%) | 82 (40%) | 41 (45%) | 5 (50%) |
| Any immune-related comorbid conditions7 | 17 (11%) | 23 (22%) | 10 (20%) | 29 (14%) | 19 (21%) | 2 (20%) |
| Hospitalization Characteristics | ||||||
|
| ||||||
| Day 7 FSS8 | 14 [7, 18] | 14 [9, 18] | 15 [12, 18] | 13 [8, 18] | 15 [10, 20] | 17 [16, 27] |
| ΔFSS Day 7: Total score | 1 [0, 7] | 5 [1, 10] | 6 [2, 9] | 2 [0, 8] | 5 [0, 9] | 4 [0, 9] |
| Neurologic insult(s) during PICU stay | 46 (30%) | 42 (40%) | 30 (60%) | 73 (35%) | 39 (42%) | 6 (60%) |
| Cardiopulmonary resuscitation | 3 (2%) | 6 (6%) | 3 (6%) | 8 (4%) | 4 (4%) | 0 (0%) |
| Cumulative 28-day PELOD | 44 [26, 75] | 53 [31, 82] | 56 [38, 102] | 45 [27, 74] | 59 [35, 94] | 60 [45, 103] |
| Hospital LOS (days) | 13 [8, 23] | 18 [12, 25] | 19 [13, 31] | 14 [9, 22] | 20 [12, 28] | 24 [13, 55] |
| PICU LOS (days) | 8 [5, 13] | 10 [5, 15] | 11 [6, 16] | 8 [5, 13] | 11 [5, 16] | 11 [6, 22] |
| Ventilation (days) | ||||||
| 9 days or less | 104 (68%) | 63 (59%) | 28 (56%) | 138 (67%) | 52 (57%) | 5 (50%) |
| 10+ days | 48 (32%) | 43 (41%) | 22 (44%) | 68 (33%) | 40 (43%) | 5 (50%) |
Area deprivation index (ADI) was unavailable for 58 patients.
Other insurance selections included: do not know, no insurance, and self-pay.
Patients categorized based on data collected within the pediatric health information system (PHIS) for the 3 years prior to LAPSE index ICU admission. PHIS data was unavailable for 1 patient.
Day 1 PELOD refers to the calculated PELOD 2 score on the calendar day of PICU admission if subject was admitted before noon. If admitted after noon, it refers to the following day.
PRISM III score uses the worst physiologic values obtained during the 6-hour period from 2 hours prior to PICU admission through four hours post PICU admission.
Documented infections were collected from PICU admission until day 28 or ICU discharge, whichever occurred first.
Immune-related comorbid conditions were collected daily from PICU admission until Day 28 or PICU discharge, whichever occurred first.
Relative to pre-sepsis baseline.