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. 2022 Jun 3;13:911919. doi: 10.3389/fimmu.2022.911919

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Copyright © 2022 Yue, Gao, Li, Xing, Qian, Hu, Wang and Hua

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Therapeutic intervention by enforcing CD155-TIGIT axis. The current strategies are being investigated to block autoreactive T cell responses via TIGIT signaling pathway: recombinant TIGIT-Ig fusion protein; TIGIT overexpression; agonist anti-TIGIT Ab, and recombinant CD155. In addition, antagonistic anti-CD226 Ab could also inhibit the stimulatory function of T cells.