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. 2022 Jun 3;12:908907. doi: 10.3389/fonc.2022.908907

Table 2.

Characteristics of the patients grouped immune cells and peripheral blood.

Variables NLR P PLR P LMR P CD3 P CD4 P CD8 P
<2.00 ≥2.00 <117.60 ≥117.60 <4.02 ≥4.02 <93.5 ≥93.5 <56.5 ≥56.5 <54.5 ≥54.5
Age (year)
<60 20 16 0.001 19 17 0.370 20 16 0.175 16 20 0.358 19 17 0.646 22 14 0.066
≥60 7 33 17 23 16 24 22 18 19 21 16 24
Gender
Male 18 23 0.512 21 20 0.467 18 23 0.512 18 23 0.250 21 20 0.818 23 18 0.198
Female 9 26 15 20 18 17 20 15 17 18 15 20
Tumor stage
T1-T2 16 16 0.025 17 15 0.391 5 27 0.003 9 23 0.001 18 14 0.691 9 23 0.001
T3-T4 11 33 19 25 31 13 29 15 20 24 29 15
Lymph node metastasis
No 18 33 0.952 23 28 0.571 23 28 0.571 19 32 0.002 26 25 0.807 18 33 0.001
Yes 9 16 13 12 13 12 19 6 12 13 20 5
Bismuth-Coretre type
I-II 16 17 0.039 17 16 0.526 16 17 0.864 11 22 0.011 13 20 0.105 12 21 0.025
III-IV 11 32 19 24 20 23 27 16 25 18 26 17
Tumor differentiation
Moderate/poor 23 42 0.949 34 31 0.036 30 35 0.606 33 32 0.744 31 34 0.328 33 32 0.744
well 4 7 2 9 6 5 5 6 7 4 5 6
Tumor size (cm)
<3 19 31 0.532 22 28 0.015 26 24 0.262 26 24 0.472 23 27 0.231 25 25 0.688
≥3 8 18 16 10 10 16 12 14 16 10 13 13
Liver invasion
No 22 41 1.000 29 34 0.607 30 33 0.923 33 30 0.361 29 34 0.128 29 34 0.128
Yes 5 8 7 6 6 7 5 8 9 4 9 4
Neural invasion
No 8 14 0.922 8 14 0.220 13 9 0.191 8 14 0.129 12 10 0.613 7 15 0.052
Yes 19 35 28 26 23 31 30 24 26 28 31 23
Portal vein invasion
No 16 21 0.171 17 20 0.809 13 24 0.037 11 26 0.001 18 19 0.818 12 25 0.002
Yes 11 28 19 20 23 16 27 12 20 19 26 13
CEA (ng/ml)
<5.0 22 43 0.457 30 35 0.486 34 31 0.036 32 33 0.744 32 33 0.744 34 31 0.328
≥5.0 5 6 6 5 2 9 6 5 6 5 4 7
CA19-9 (U/ml)
<37 13 12 0.035 14 11 0.291 16 9 0.052 8 17 0.028 14 11 0.464 7 18 0.007
≥37 14 37 22 29 20 31 30 21 24 27 31 20
Total bilirubin(μmol/L)
<34.2 4 9 0.693 7 6 0.546 8 5 0.261 3 10 0.033 9 4 0.128 7 6 0.761
≥34.2 23 40 29 34 28 35 35 28 29 34 31 32

CEA, carcinoembryonic antigen; CA, 19-9 cancer antigen 19-9; NLR, neutrophil lymphocyte ratio; PLR, platelet lymphocyte ratio; LMR, lymphocyte monocyte ratio.