Axial MR images from a glioblastoma patient with true progression. The postcontrast T1 (PC-T1)-weighted image shows a ring-enhancing lesion in the left parietal region. Coregistered diffusion tensor imaging-derived parametric maps and cerebral blood volume (CBV) maps are shown. Increased mean diffusivity (MD) and coefficient of spherical anisotropy (CS), and decreased fractional anisotropy (FA), coefficient of linear anisotropy (CL), and coefficient of planar anisotropy (CP), are observed from the enhancing part compared with the contralateral normal white matter regions. The enhancing part of the lesion is also demonstrating high blood volume on CBV maps. FLAIR, fluid-attenuated inversion recovery