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. Author manuscript; available in PMC: 2022 Dec 15.
Published in final edited form as: Cancer Res. 2022 Jun 15;82(12):2313–2326. doi: 10.1158/0008-5472.CAN-21-4145

Figure 5. Graphical summary.

Figure 5.

Our data suggest that p38 inactivity reduces NR2F1 levels in normal mammary epithelial cells (left) and MMTV-HER2 ECCs (right). In the latter scenario, NR2F1 downregulation led to a partial EMT, a shift β-catenin localization from membrane to nuclei and a hybrid luminal/basal phenotype allowing dissemination of ECCs to distant organs. Thus, NR2F1 acts as a barrier for early dissemination and its loss in early lesions could indicate the presence of early disseminated cancer cells (eDCCs). Image by Jill Gregory. Used with permission of ©Mount Sinai Health System.