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. 2022 Jun 3;13:844877. doi: 10.3389/fendo.2022.844877

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Copyright © 2022 Gavin, Sullivan, Maltzahn, Jackman, Libby, MacLean, Kohrt, Majka and Klemm

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HSCDA ablation elicited insulin resistance. No differences were noted in (A) circulating glucose, (B) non-esterified fatty acid (NEFA) or (C) triacylglycerol serum levels between fasted transplant-naïve (black/white crosshatch bars), Competent (black/green crosshatch bars) and Ablated (solid black bars) cohorts. (D) Likewise, all cohorts (transplant-naïve = black/white circles, Competent=black green circles, Ablated=solid black circles) exhibited the same time course of blood glucose disposal when challenged with an oral glucose bolus. (E) Insulin-stimulated glucose disposal was significantly inhibited in Ablated mice. (n=8 per cohort, *indicates p≤0.05) (AUC = Area Under the Curve).