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. 2022 Jun 3;13:875994. doi: 10.3389/fimmu.2022.875994

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Copyright © 2022 Mycko, Zurawska, Selmaj and Selmaj

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Validation of the differential downregulation of the selected circRNAs in RRMS. (A) The expression levels of the indicated circRNAs were analyzed via qRT-PCR. Significance was determined by analysis of variance (ANOVA) with the Scheffé post-hoc test. *P < 0.05, ***P < 0.0005. The dotted line represents the mean value ( ± SD). (B) Receiver operating characteristic (ROC) curves for the comparison of hsa_circ_101145, hsa_circ_001896, and hsa_circ_100772 expression levels in RRMS relapse versus control, RRMS remission versus control, and RRMS relapse versus remission.