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. Author manuscript; available in PMC: 2022 Nov 26.
Published in final edited form as: Nat Genet. 2022 May 26;54(6):874–884. doi: 10.1038/s41588-022-01076-1

Extended Data Fig. 4. Co-depletion of NFIA and NFIX strongly reactivates γ-globin in human-to-mouse xenotransplants.

Extended Data Fig. 4

a, Percentage of human CD45+ cells in the bone marrow of the transplanted NBSGW mice (n = 5 mice/biological replicates). b, Composition of myeloid, B cells, and HSPCs from CD45+ sorted population and percentage of erythroid cells from hCD45- cells (n = 5 mice/biological replicates). c-e, Indel analysis of NFIA, NFIX, and BCL11A in input HSPCs, total engrafted cells, B cells, T cells, and HSPCs isolated from indicated recipient animals 16 weeks post-transplantation (n = 5 mice/biological replicates). Data are expressed as means ± SEM.