Skip to main content
. 2022 Jun 3;12:910678. doi: 10.3389/fonc.2022.910678

Figure 2.

Figure 2

LncRNA is involved in EMT in PDAC through different pathways. Most known LncRNA can act as competing endogenous RNAs (ceRNA) to sequester target miRNA away from mRNA or DNA thus regulating the expression of downstream proteins. LncRNAs, such as XLOC_000647, NE5T, and HOTTIP, can regulate gene expression by binding with local chromatin architectures which localize physically nearby. LncRNAs,such as RoR, BX111, LINC01133, and CASC9, can directly regulate or interact with EMT-related proteins or further affect the expression of its downstream targets. However, some lncRNAs, such as MALAT-1, TUG1, LINC00261, PVT I, ANRIL, MEG3, HOTAIR, SUMO1P3, and LINC01296, play an important role in the EMT process with unclear mechanisms. Red arrows: the pathway promotes EMT, green arrows: the pathway inhibits EMT, the black circle: the proteins regulated by ceRNA and positively regulates EMT.