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. 2022 Jun 3;13:875695. doi: 10.3389/fphar.2022.875695

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Copyright © 2022 Keritam, Juhasz, Schöfer, Thallinger, Aretin, Schabbauer, Breuss, Unseld and Uhrin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative images of treated area in mice at day five after treatment with (A) trabectedin (grade 3), (B) trabectedin and hyaluronidase (grade 3), (C) trabectedin and tacrolimus (grade 2), (D) trabectedin and DMSO (grade 2). (E) Extent of skin changes assessed by grading. (F) Size of affected skin area in lesions graded at least as grade 2, statistically analyzed using ANOVA followed by a post-hoc test with a Tukey-B correction *p < 0.05, ***p < 0.005, ns = not significant. Scale bar is 1 cm.