Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 3;10:826576. doi: 10.3389/fcell.2022.826576

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Biswas, Zhao, Makinwa, Bassett, Musich, Liu and Zou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Proposed prolyl isomerization-mediated conformational changes and subcellular compartment-specific functions of ATR. Mass footprinting revealed changes in the surface topology of ATR in the cytoplasm and the nucleus. After UV irradiation, cytoplasmic ATR undergoes multiple conformational changes that open up the BH3 domain and allow tBid–ATR interaction, whereas, in the nucleus, UV irradiation enhances the ATR–ATRIP association, which may help retain the trans-ATR conformation and allow the ATR–ATRIP complex to interact with RPA-bound ss-DNA and the subsequent binding of other ATR activators (like TOPBP1), further enhancing ATR kinase activity.