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Crosstalk between RTK/non-RTK and other signaling pathways. PDGFR activates NF-κB signaling through the PI3K/Akt pathway. Integrins participate in EMT of epithelial cells through SFK/β-catenin-mediated signaling. TGF-β/Smad signaling interacts with the CTGF, Src, Fyn, and Notch pathways to participate in EMT in epithelial cells. Different subtypes of FGF and VEGF have different pro- or antifibrotic effects.
