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. 2022 Jun 3;13:899609. doi: 10.3389/fimmu.2022.899609

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Copyright © 2022 Cannon, Holloman, Wilson, Miranda, Dopkins, Nagarkatti and Nagarkatti

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of changes in cellular types following ConA-induced hepatitis using scRNA-seq. C57/BL6 mice were injected with ConA followed by vehicle or TCDD 1 hour later as described in Figure 1 legend. Liver infiltrating cells were isolated and scRNA-seq was performed as described in Methods. (A) tSNE plot with each treatment group separated by color and main clusters labeled. (B) tSNE plot separated by sample group and colored to show varying stages of activation and differentiation (C) Heatmap of the percentages of cells contained in each tSNE cluster with the increases in the percentage shown by the change in color from light to dark.