Figure 6.

Srgn, Ccl5, and Cd52 identified as dysregulated genes of interest in Naïve T Cell and Memory CD8+ T Cell clusters. C57/BL6 mice were injected with ConA followed by vehicle or TCDD 1 hour later as described in Figure 1 legend. Liver infiltrating cells were isolated and scRNA-seq was performed as described in Methods. Heatmaps consisting of the top 50 differential genes per treatment were generated using Loupe Browser. Heatmaps of differentially expressed genes from (A) Naïve T cells and (B) Memory CD8+ T cells. (C–E) Violin plot of Log2 expression of target genes.